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Literature summary for 4.2.1.56 extracted from

  • Kronen, M.; Sasikaran, J.; Berg, I.A.
    Mesaconase activity of class I fumarase contributes to mesaconate utilization by Burkholderia xenovorans (2015), Appl. Environ. Microbiol., 81, 5632-5638 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.1.56

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Itaconyl-CoA + H2O Paraburkholderia xenovorans the enzyme is involved in the degradation of itaconate Citramalyl-CoA
-
 ?
Itaconyl-CoA + H2O Paraburkholderia xenovorans DSMZ 17367 / LB400 the enzyme is involved in the degradation of itaconate Citramalyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Paraburkholderia xenovorans
-
-
-
Paraburkholderia xenovorans DSMZ 17367 / LB400
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Itaconyl-CoA + H2O
-
 Paraburkholderia xenovorans Citramalyl-CoA
-
 ?
Itaconyl-CoA + H2O the enzyme is involved in the degradation of itaconate Paraburkholderia xenovorans Citramalyl-CoA
-
 ?
Itaconyl-CoA + H2O
-
 Paraburkholderia xenovorans DSMZ 17367 / LB400 Citramalyl-CoA
-
 ?
Itaconyl-CoA + H2O the enzyme is involved in the degradation of itaconate Paraburkholderia xenovorans DSMZ 17367 / LB400 Citramalyl-CoA
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay Paraburkholderia xenovorans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Paraburkholderia xenovorans

Expression

Organism Comment Expression
Paraburkholderia xenovorans substantially downregulated in acetate-grown cells down
Paraburkholderia xenovorans high activities of itaconyl-CoA hydratase in cell extracts of itaconate-grown Paraburkholderia xenovorans up

General Information

General Information Comment Organism
metabolism the enzyme is involved in the degradation of itaconate. Itaconyl-CoA hydratase reaction as a bottleneck in the conversion. Its activity is an order of magnitude lower than the activities of itaconate-CoA transferase and (S)-citramalyl-CoA lyase Paraburkholderia xenovorans